Published on 8/30/18 on PR Newswire

Collaborations will explore applications of two distinct families of novel polyphosphazenes in breast cancer tumor detection and medical device coatings.

The Institute for Bioscience and Biotechnology Research (IBBR) has entered into two separate collaborations involving its polyphosphazene (PPZ) polymer platform. PPZs are synthetic, biofunctional macromolecules with the potential to advance a wide range of biomedical capabilities. IBBR Fellow, Dr. Alexander Andrianov, is working with collaborators to develop new PPZs for use as coatings for medical devices and as carriers of medical imaging agents.

Developing self-healing and biocompatible polyphosphazene coatings for stents and other indwelling medical devices

“Academic and industry collaborations are the essence of our mission to develop solutions to major health, scientific, and technological challenges that enhance life through science and discovery,” said Dr. Thomas Fuerst, IBBR Director.  “We are proud to leverage our novel polyphosphazene expertise in polymer sciences to complement the visionary research being done at the University of Pennsylvania and Texas A&M University.”

The surface of implanted medical devices – like cardiac stents, catheters, and artificial joints – are often coated with polymers. Dr. Andrianov and his collaborator, Dr. Svetlana Sukhishvili (Professor and Director, Soft Matter Facility, Texas A&M University), recently received funding from the National Science Foundation to support the development of new, highly biocompatible, non-biodegradable, PPZ-based coatings that are capable of controlled drug release.

Dr. Andrianov notes, “One of remarkable features of these PPZ coatings is their self-healing capability, which means that even minor damage to the film surface can ‘smooth itself out,’ decreasing the potential for unwanted tissue growth and bacteria build-up.”

In another collaboration, Dr. Andrianov is working with Dr. David Peter Cormode (Associate Professor of Radiology, Perelman School of Medicine at the University of Pennsylvania) to apply PPZ technology toward earlier breast cancer detection. Dr. Cormode was recently awarded a National Cancer Institute grant to develop silver-based contrast agents to enhance breast imaging by a technique called dual-energy mammography. Dr. Andrianov will synthesize, purify, and characterize PPZs suitable for making biodegradable nanoparticles with superior in vivo half-life to encapsulate the new contrast agents.

Dr. Andrianov’s PPZ research at IBBR was initially supported through a seed grant from the University of MarylandStrategic Partnership: MPowering the State, a program designed to leverage the strengths and missions of the University of Maryland College Park and the University of Maryland Baltimore to enhance the State of Maryland’s innovation economy, advance interdisciplinary research, create opportunities for students, and solve important problems for the people of Maryland and the nation.

About IBBR 

IBBR is a University System of Maryland joint research enterprise among the University of Maryland College Park, the University of Maryland Baltimore, and the National Institute of Standards and Technology (NIST).  The Institute serves as the nexus between academic research and commercial application, bringing together all of the critical elements necessary to pursue solutions for major scientific and medical challenges.  Through collaboration and interaction among academia, government and industry, IBBR focuses on structure-based design, characterization and testing of proteins and nucleic acids, and conducting groundbreaking research to develop innovative translational applications.  IBBR leverages its unique infrastructure and capabilities to advance projects and innovations towards commercialization in real world applications.  The Institute also serves to expand the economic base of science and technology in the state of Maryland and at the national level.

For more information and collaborative opportunities at IBBR, contact:

Viqar Aslam

Director, Business Development and Strategy

Institute for Bioscience and Biotechnology Research

University of Maryland

9600 Gudelsky Drive | Rockville, MD | 20850 

vaslam@umd.edu | 240.314.6373

SOURCE Institute for Bioscience and Biotechnology Research

Related Links

https://www.ibbr.umd.edu