Posted on 10/3/18 on PR Newswire

New computational tool supports the engineering and development of cancer immunotherapies by predicting how T cell receptors recognize and bind to their targets

ROCKVILLE, Md.Oct. 3, 2018 /PRNewswire/ — The Institute for Bioscience and Biotechnology Research (IBBR) has been awarded a $1.2M National Institute of Health (NIH) grant to generate a robust modeling and design framework to predict the structures of T cell receptors (TCRs) from sequence, model antigen recognition, and design new TCRs with desired targeting capabilities that can be applied in therapies against cancer and other diseases. Dr. Brian Pierce, IBBR Scientist and Assistant Professor, University of Maryland Department of Cell Biology and Molecular Genetics, is the project’s principal investigator. Pierce is also an investigator in the University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center’s Tumor Immunology and Immunotherapy Program.